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Payer policies change annually, and coverage criteria for Xiaflex can include step-edit requirements, like prior conservative treatment, that differ from one plan to the next

The strategy of interrogating a single growth-hormone-axis pathway through a defined molecule parallels the contemporaneous lineage of growth-hormone secretagogues such as CJC-1295 with DAC, which pursued the complementary aim of prolonging endogenous GH release rather than isolating a fragment

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