& Lahav, G
In general, these enzymes catalyze the transfer of sulfonate (SO 3 ) from the universal sulfonate donor 3phosphoadenosine 5phosphosulfate (PAPS) to the hydroxyl or amino group of an acceptor molecule, Fig
However, under cellular conditions, the concentration (110 mM) of GSH is several folds higher than of hydroperoxides (10100 M), and thus, the velocity ( V max ) of the detoxification of hydroperoxides by seleno-GPxs is practically independent of the concentration of GSH [8, 17, 18]
Through the gut-brain axis and systemic anti-inflammatory effects
Its primary biological function is to protect cellular machinery from oxidative stress by neutralizing reactive oxygen species (ROS), such as superoxide radicals and hydrogen peroxide, which are natural but destructive byproducts of cellular energy production
We also include cofactors that support the body's natural recycling pathways, making the supplement more effective over the long term