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Inadequate use of vitamin B 12 , which may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia Pernicious anemia is the most common cause of vitamin B 12 deficiency

In NPC1-deficient mice and several phase 1/2a trials, both intrathecal and intravenous administration [7,8,9] of HPCD reduced cholesterol accumulation with beneficial effects for neurological symptoms, and improved liver dysfunction [7, 70]

It is found in two different forms

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10.1073/pnas.0806139105 Proc

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