Proposed axes such as lung-heart ferroptotic coupling are intriguing but currently rest largely on correlative in vivo imaging, inflammatory signaling, and systemic oxidative stress markers rather than direct causal relay experiments
GSH plays a crucial role in protecting cells from ROS-induced damage and supports protein and DNA synthesis by regulating redox status []
OCR was determined by six measurement cycles before and after injection: 3 min mixing, 3 min waiting and 3 min measuring
Yepthe liver
Wang W, Qi Y, Rocca JR, Sarnoski PJ, Jia A, Gu L
GSH-activated prodrugs, including disulfide- and diselenide-linked conjugates, are selectively activated in tumors, enabling high drug loading and targeted delivery