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Clinical data supports the idea that staying on a stable dose preserves weight loss benefits indefinitely

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doi:10.1056/NEJMoa011573 22Heidary N, Naik H, Burgin S

The weekly schedule follows a 5-days-on, 2-days-off pattern

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The observed alleviation of this inhibition (by NaBH 4 -reduced gliotoxin), in the presence of added GSH, supports the proposal that intracellular GSH depletion is a consequence of gliT disruption, when growth occurs in the presence of exogenous gliotoxin