Trimethylamine can temporarily build up in the bloodstream and is released in the person's urine, sweat, and breath, giving off a rotten fish odor
Unlike caffeine, which impacts the central nervous system, theobromine primarily influences smooth muscle, acting as a natural muscle relaxer
doi: 10.1038/ijo.2012.208 236 LockieSHHeppnerKMChaudharyNChabenneJRMorganDAVeyrat-DurebexCet al
During human medication trials, if someone reports ANYTHING to the researchers, it must be listed as a possible side effect
The events did not lead to significant dropout rates in the trial
In SURPASS trials, patients on metformin plus tirzepatide achieved HbA1c reductions of 2.0-2.5%, with many reaching HbA1c targets below 5.7% (normal range)