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WhiteMPAlcockIGrellierJWheelerBWHartigTWarberSLet al

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doi: 10.1080/14397595.2020.1868675 31 LiuXNiSLiCXuNChenWWuMet al

Minimal reported adverse effects but lacks Phase 3 validation

Symptoms of severe vitamin B12 deficiency can include visual disturbances, severe joint pain, paresthesia (tingling in the hands and feet), memory problems, depression, anxiety, poor muscle function, ataxia (impaired balance and coordination), changes in reflexes and even infertility