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Weigh to Go: Assessing the Wider Implications of a Slimmer Society
On the basis of results of the most recent CVOTs (DAPA-HF, DAPA-CKD, EMPEROR-R), the FDA has approved dapagliflozin (2020) and empagliflozin (2021) to reduce risk for CV death and HF hospitalization in adults with HF and reduced ejection fraction regardless of whether they have diabetes [24, 25]
Participants taking the highest dose of orforglipron (36 mg) experienced a mean weight loss of 7.3 kg , or 7.9%, compared with 1.3 kg or 1.6% in the placebo group
Dietary Sources vs
Early 2023 ASA guidance favored holding daily agents on the day of surgery and weekly agents for one week, but 2024 multi-society guidance now recommends that most patients continue therapy before elective procedures
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