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This is consistent with earlier data showing high levels of DHA in brain tissue,5-6 and the report of low DHA content in the brain of individuals with Alzheimer disease.7 A number of investigators8-9 have previously analyzed the links between plasma DHA status and dementia and documented lower plasma phospholipid or cholesteryl ester DHA content in patients with dementia or impaired cognitive function compared with healthy elderly subjects

Thats why clinical studies consistently use brief courses of 1020 days, sometimes repeated annually or semiannually, to achieve long-term benefits