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In contrast, SGLT2i have metabolic effects on the myocardial and renal cells that mimic energy starvation, simulating autophagy and other changes that counteract the progression of HF

It raises decorin levels by 302%, a proteoglycan that organizes collagen into stable, functional structures

No existe una dosis universal para todos los pacientes

Nausea and digestive discomfort Eat three balanced meals a day based on whole foods Choose easy-to-digest foods during the first few weeks, such as scrambled eggs, white fish, and cooked vegetables Stay well hydrated between meals (aim for 2 litres daily) Limit the intake of ultra-processed foods and takeaways Consider ginger tea or supplements, which may help reduce nausea in some people Fatigue Ensure adequate protein intake at each meal Include iron-rich foods like red meat and spinach alongside vitamin C sources Maintain consistent sleep habits Dont skip meals, even if your appetite is reduced Changes in appetite Maintain three balanced meals a day based on whole foods, even if hunger is low Include a protein-rich food at each meal, roughly a palm-sized portion Include plenty of non-starchy vegetables to maximise the nutrient density of meals Plan healthy snacks for times when hunger might increase Most transition-related side effects resolve within 2-4 weeks as the body adjusts to the new medication

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