Common side effects may include: Nausea: Especially after meals or following a dose increase Vomiting: Triggered by persistent or severe nausea Constipation: Due to slower digestion and reduced food intake Diarrhea: Including loose stools or changes in bowel habits Bloating: Caused by delayed stomach emptying Abdominal discomfort: Such as mild cramping, pressure, or digestive upset Tips to manage GLP-1 side effects Reduce portion sizes Many patients find that eating smaller meals helps reduce nausea and digestive discomfort
G.et al (2003)
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These factors include tobacco and alcohol consumption, poor diet, low levels of physical activity, being overweight, and individuals who are over 55 years old
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In isolated perfused porcine ileum, GLP-1 secretion could be increased by infusion of acetylcholine during coinfusion of phentolamine (an -adrenergic blocker, which will eliminate the sympathetic inhibition of GLP-1 secretion) (97)