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There are no randomized, placebo-controlled efficacy data in humans

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doi: 10.1097/00004703-199906000-00005 8 DrakeCNickelCBurduvaliERothTJeffersonCPietroB

Physiologically, patients with asthma frequently experience disruptions in their melatonin levels, namely a delayed acrophase in peak serum concentrations, as well as in the amount of GSH produced in the lung (15, 21)