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Managing and Preventing Adverse Reactions To stop bad reactions, start with the right screening and teaching patients

Clinical Trial Dosing Ranges Dose Titration Schedules Clinical trials have employed gradual dose escalation to minimize gastrointestinal side effects [9] : Standard Titration Protocol (Example from ONWARDS 1) Rationale: Gradual titration allows tolerance development to gastrointestinal effects (particularly nausea) while building up to therapeutic doses

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Injection is given once a week if levels are low and once a month for maintenance

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