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The practical impact of metabolic withdrawal: large-scale population studies suggest that individuals who use and then discontinue GLP-1RAs before pregnancy may experience excessive gestational weight gain (GWG) and an increased risk of gestational diabetes mellitus (GDM) and gestational hypertension (137)

Topiramate , often combined with phentermine, supports long-term weight management by helping control cravings, promote satiety, and enhance adherence to healthier habits

Heat intolerance is not listed as a direct side effect of semaglutide, but GLP-1-related dehydration can weaken the body's cooling ability

A gradual taper involves slowly lowering your dose over several weeks or months

Cuadrado et al., 2019