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While clinical validation of this mechanistic advantage continues to evolve, the dual-inhibition profile positions Polmacoxib as a promising therapeutic option for managing osteoarthritis

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10.1016/j.neuroscience.2012.01.031 57 ParfenovaH.BasuroyS.BhattacharyaS.TcheranovaD.QuY.ReganR

Fewer amino acids mean fewer potential degradation sites and simpler folding that is more resistant to thermal denaturation

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