sar425899 sanofi dual agonist glp-1 glucagon New Generation Oxyntomodulin Peptides with Improved Pharmacokinetic Profiles Exhibit Weight Reducing and Anti-Steatotic Properties in Mice Retatrutide, a GIP, GLP-1 and

Genes Nutr

A research study in rats suffering from retinitis pigmentosa demonstrated that the peptide improved results in 90% of cases

PLoS One 8 (4), e61217

doi: 10.1073/pnas.1906908116 Summary Keywords cognitive function, neuroinflammation, oxidativestress, plant-based nutrition, thyroidbrain axis Citation Zhang Z, Xu M-X, Wang N, Shen R, Sun J, Zha M and Wang M (2026) Plant-derived nutritional components in thyroid disease-related neuropsychiatric disorders: mechanistic insights and advances

(JCEM 2006) They documented a 2- to 10-fold increase in plasma GH (dose-dependent), a 1.5- to 3-fold increase in IGF-1 for 9-11 days, and a half-life of 5.8 to 8.1 days

No completed randomized controlled human trials exist for any indication as of 2026