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The Jastreboff Phase 2 trial randomised 338 adults with body mass index 30 (or 27 with at least one weight-related condition) to retatrutide 1, 4, 8, or 12 mg subcutaneously once weekly, or placebo, for 48 weeks
Certain combinations of symptoms, such as painless jaundice or persistent upper abdominal pain with weight loss, may prompt urgent referral under NICE suspected cancer guidelines (NG12)
Because the drug stimulates melanin production, many light-skinned patients have found that their existing moles and marks become darker
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