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The rationale for pulsed dosing originates from Khavinson's broader theory of peptide bioregulation
Because glucagon receptor signalling is part of the design, research discussions also pay attention to hepatic markers, lipid markers, and other cardiometabolic endpoints in substudies
PMID: 9390009 Haruta I, et al
This can result in a depletion of amino acids and key nutrients (such as zinc, selenium, B12, and iron/ferritin) needed for thyroid support, as well as for the synthesis of non-essential amino acids
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