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Doses are gradually increased to minimize side effects

Many people with diabetes struggle to maintain a healthy weight, and carrying extra weight can make diabetes harder to control

Otto C, Klingelhffer C, Biggermann L, Melkus G, Mrchel P, Jrgens C et al

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(5) Metformin may also enhance GLP-1 secretion via the M3 cholinergic receptor and the gastrin-releasing peptide (GRP) receptor

Alternatively, if approval is granted on a higher-than-necessary level of dosage, it is possible that tablets may be prescribed or subsequently used at a lower dose level (post-marketing dose reduction) to manage any undesirable effects