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The needles are tiny (insulin-style), the injection takes 15 seconds, and most patients are comfortable self-administering after one training session

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Worsening neurological symptoms : Progressive weakness, worsening balance problems, or deteriorating cognitive function despite treatment requires urgent assessment

Clinical Endocrinology & Metabolism (2005)Coviello AD et al: low-dose hCG maintains intratesticular testosterone during testosterone-induced gonadotropin suppression

The 250 mcg community protocol above is the conservative standard

For most adults injecting into the abdominal wall with a half-inch needle, 90 degrees is appropriate