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The short answer from clinical trial data: not necessarily
This is why people taking GLP-1 agonists like Wegovy often report feeling satisfied longer after eating and experience reduced food cravings
The most common physical abnormality is mild hepatomegaly with chronically elevated levels of the transaminases, AST and ALT
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Some or all of the lower repeat-overdose risk could reflect those kinds of differences rather than the medication itself
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