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Results demonstrated that AOD-9604 displayed a very good safety and tolerability profile indistinguishable from placebo. Critically, the peptide produced no clinically significant alterations in IGF-1 levels, no glucose intolerance or insulin resistance, and no anti-AOD9604 antibodies in any participant

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Wang W, Zhang Y, Huang W, Yuan Y, Hong Q, Xie Z, et al

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Other studies have also demonstrated that integrins organize and stabilize the plus ends of microtubules at the basal surface of epithelial cells, which is necessary for epithelial polarity and lumen formation [13]

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