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Metabolic disease and ABHD6 alter the circulating bis(monoacylglycerol)phosphate profile in mice and humans

Pregnancy and lactation represent relative contraindications given absence of human safety data in these populations despite reassuring preclinical reproductive toxicology studies

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Second, research in animal models suggests that semaglutide activates GLP-1 receptors in the central nervous system, particularly in the brainstem area postrema and nucleus tractus solitarius, which are regions responsible for controlling nausea and vomiting responses