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It is still unknown whether mutant SOD1 fibrils initiate ferroptosis by disrupting mitochondrial iron homeostasis, for example by promoting ironsulfur cluster release, or how lipid peroxidation products generated during ferroptosis (such as 4-HNE) accelerate TDP-43 nuclearcytoplasmic mislocalization and aggregation

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Nat Prod Rep (2013) 30:52545

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