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The trial in people with T2D included 281 participants (mean age 56 years, 56% women, mean BMI 35.0 kg/m 2 , mean HbA1c 8.3%) treated with lifestyle only and/or metformin, with similar intervention arms to the obesity trial, albeit retatrutide 0.5 mg rather than 1 mg, and dulaglutide 1.5 mg was an additional comparator [46]

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In the matched expanded populations, the mean age ranged from 59.2 to 69.2 years, 50.455.8% were female and the mean body mass index (BMI) ranged from 34.5 to 38.7 kg m 2