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GLP-1, glucagon-like peptide 1
Before the start, approval was obtained under reference number 1/2022 PEDI 44 from the Institutional Research Board in Menoufia Faculty of Medicine, which works in accordance with the Declaration of Helsinki, and the trial was registered at the Pan African Clinical Trials Registry under number (PACTR202401875833105)
Step 14 Add 50l of Stop Solution to each well
[1] Beyond glycemic control, these medications slow gastric emptying, which prolongs satiety and reduces appetite through central nervous system pathways involving the hypothalamus and brainstem
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Conclusions The antifibrotic effects of GLP-1R activation on pulmonary fibrosis could be attributed to the inhibition of the interaction between NLRP3 inflammasome and PFKFB3-driven glycolysis, and histone lactylation in lung fibroblasts
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