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Three receptors
Mechanistically, finasteride has been proven to be 5-R2 inhibitor by acting on alternative substrate for 5-R2 which is initially bound to highly stable complex of enzyme-bound NADP-dihydrofinasteride
References: Gwyer D et al
The review confirmed that NNMT-mediated NAD+ depletion impairs mitochondrial function, SIRT activity (particularly SIRT1 and SIRT3), redox balance, and energy metabolism, creating conditions relevant to cardiovascular disease research models
How to prevent it: Start at 2 to 3 times per week for the first 2 weeks
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