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Ethics declarations Ethics approval and consent to participate The protocol was approved by local ethics committees and institutional review boards at each participating center

doi:10.1038/s41591-022-02026-4 2

If retatrutide's greater efficacy in weight and metabolic parameters translates to cardiovascular outcome data of comparable or superior magnitude, the case for its use as a longevity intervention, not merely an obesity treatment, will be scientifically compelling

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