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Alegre J, Roses JM, Javierre C, Ruiz-Baques A, Segundo MJ, et al

The fundamental need for ammonia-mediated induction of autophagy in cancer cells could be due to the cytoprotective functions of this event that allow cells to survive under extreme conditions 166

Glutathione is considered to be one of the bodys most powerful antioxidants, involved in a number of enzyme systems necessary for detoxification, the neutralization of free radicals and maintaining blood- brain barrier function

For instance, USM [H]L vesicles integrate encapsulated enzymes to degrade uric acid and hydrogen peroxide, generate photothermal effects for inflammation disruption, repolarize M1 macrophages to M2 phenotypes, and reprogram metabolic/immunological pathways for gout resolution (Yang et al., 2020)

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