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#Healthcare #Biotech #Pharmaceuticals #Diabetes #Obesity #Innovation #ClinicalTrials To view or add a comment, sign in Anti-Obesity Drugs 1 Appetite Suppressants (Central Acting Agents) Mechanism: Reduce appetite Increase satiety Act on CNS (hypothalamus) Examples: Phentermine Phentermine + Topiramate Bupropion + Naltrexone 2 GLP-1 Receptor Agonists Mechanism: Increase insulin secretion Delay gastric emptying Promote satiety Examples: Liraglutide Semaglutide 3 Dual GIP & GLP-1 Agonist Example: Tirzepatide 4 Fat Absorption Inhibitors Mechanism: Inhibit pancreatic lipase Reduce dietary fat absorption Examples: Orlistat Cetilistat 5 Other / Adjunct Drugs Metformin (used in insulin resistance) Zonisamide (off-label) Therapeutic Effects Decrease appetite Increase fullness Reduce fat absorption Promote weight loss Improve metabolic parameters Important Note Lifestyle modification (diet + exercise) is essential along with medication

If these mechanisms translate consistently into humans, this could reshape how we think about patient selection and treatment goalsespecially in individuals who may not achieve substantial weight reduction but still derive meaningful hepatic benefit

Large cohort studies and meta-analyses show no substantial long-term increase in thyroid cancer risk with GLP-1 RA use

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