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Lumbar spine BMD changes were 0.011 g/cm 2 (95% CI: 0.157 to 0.136) in the semaglutide group and 0.106 g/cm 2 (95% CI: 0.041 to 0.25) in the lifestyle-alone group ( p = 0.26), corresponding to 0.71% and 6.95%, respectively

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In the hypothalamus, GLP-1R activation stimulates POMC/CART neurons and inhibits NPY/AgRP neurons, producing satiety

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This slowing effect is therapeuticit helps prevent rapid rises in blood glucose after meals and contributes to improved glycaemic control