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In vitro studies on bone cells supported the expression of the conventional GLP-1R in osteoblasts and confirmed that liraglutide, at nanomolar concentrations, promoted osteoblast differentiation and reduced osteoblast apoptosis via activation of the PI3K/Akt/GSK3K, MAPK, and cAMP/PKA/-catenin intracellular pathways [46,47,48]

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This test evaluates key variants including GIPR rs1800437, FTO rs9939609, and MC4R rs17782313providing insights into how your body processes and responds to GLP-1 and GIP pathway activation

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All other authors declare no competing interests