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Further, AChE binding to the non-amyloidogenic form of -amyloid peptide (A) appears to facilitate a conformational shift to the amyloidogenic form ( , Donepezil , Rivastigmine , and Galantamine ) which will go generic in the near future ( (Memantine HCl) in 2004, an N -methyl-d-aspartate (NMDA) receptor antagonist designed to limit glutamate excitotoxicity and intended to treat moderate to severe AD patients ( There are many possible reasons for the lack of an effective therapy for AD including the complexity of the disease process and the resulting inability to identify reliable biomarkers

However, this review also noted that the quality of the studies was not very high, so more studies are needed before its possible to make any firm recommendations

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These include epigastric pain syndrome, functional dysphagia, heartburn, reflux hypersensitivity, belching disorder, bloating/distention, centrally mediated abdominal pain, fecal incontinence, and others