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Further increases can be made in 2.5 mg increments every 4 weeks as tolerated, up to a maximum of 15 mg once weekly

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Allow a complete washout period of four to six weeks before considering resumption at dramatically reduced levels

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Biological Chemistry , 390(3):191-214

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High-dose busulfan treatment is correlated with drug-related events such as cataracts and hepatic sinusoidal obstruction syndrome

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