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In your head

Lowman MA, Rees PH, Benyon RC, Church MK

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In rats, GCLC has a Km for glutamate that is about 10-fold higher than that of the GCL holoenzyme, which is higher than the cellular glutamate concentration in most tissues GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) non-allosteric feedback competitive inhibition by glutathione (GSH) (Ki = 2.3 mM) which involves binding of GSH to the glutamate and another site on the enzyme [8, 9] and (b) availability of its precursor, cysteine [1]

Your provider will check whether your colon is stable and free of active inflammation before giving the green light

International Journal of Molecular Sciences, 17(5), p.629