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Group design and comparative analysis Comparative safety profile: GLP-1 receptor agonist monotherapy versus combination therapy with metformin The pharmacovigilance analysis encompassed 262,355 adverse event (AE) reports associated with GLP-1 receptor agonist therapy

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GLP-1 RAs: FDA Indications as of February 2026 *Combination GLP-1 RA and glucose-dependent insulinotropic polypeptide RA

Apixaban has a well-characterized sensitivity to drugs that modulate CYP3A4 and P-glycoprotein (P-gp), and patients rightly worry that a newer peptide could alter its anticoagulant effect

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Overall, these results suggested that GLP-1 RA were beneficial to the cardioprotection of people with diabetic HFpEF