Classically, three metabolic alterations have been identified that contribute to the development of T2DM: 1) insulin resistance, 2) an eventual decrease in insulin secretion from pancreatic beta cells, and 3) an excess production of glucose from the liver
Li C, Navarrete J, Liang-Guallpa J, Lu C, Funderburk SC, Chang RB, et al
The job of liver detoxification is to transform these substances from fat-soluble compounds into water soluble products in order to efficiently excrete them into the urine or stool
Specifically, the Senate hearings where pharmaceutical CEOs and PBM executives sat across from Bernie Sanders and everyone yelled at each other for three hours and absolutely nothing changed
& Phillips, W
To address this, other forms have been developed