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Some contraindications (reasons not to take B12 shots) include: Allergies to cyanocobalamin or methylcobalamin Kidney or liver disease Eye issues, especially if you have Lebers disease A current infection If youre taking medication related to bone marrow You should talk to your doctor about the above conditions before getting B12 injections

These strips dissolve under the tongue and provide a slightly lower dose

A discolored or damp vial should not be used

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Taking cyanocobalamin if you have a methylation issue or MTHFR defect (3) in your genes can also cause issues as your body attempts to methylate the B12 before it can utilize it completely