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Antibodies targeting IL1- have also shown mixed, although more positive effects, particularly in reducing HbA1c with IL1- antagonism [206], with recent evidence suggesting that combined TNF-alpha and IL1- blockade may be most effective for glycemic control [207]

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Meisenhelder et al., 1989

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3-HSD converts pregnenolone to progesterone, whereas CYP17A1 catalyzes the conversion of progesterone to androstenedione 107

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