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COMT and GSTM1/GSTT1 are functionally complementary both protect against 4-OHE2 quinone accumulation through different enzymatic mechanisms
Rabbits were divided into four groups and treated for about 3 weeks, control group was named G1 and administered distilled water, while group 2 received CP at a dose of 50 mg per kg per week
ROS, including superoxide radicals, hydroxyl radicals, and hydrogen peroxide, are generated in mitochondria, peroxisomes, and the endoplasmic reticulum
doi: 10.1111/j.1439-0272.1997.tb00328.x 54 ShangXHuangYYeZYuXGuW
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When glutathione levels are depleted, detox pathways may become less efficient, allowing oxidative stress and inflammatory signaling to persist across multiple organ systems
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