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Differences in stimulation regimens, progesterone exposure timing, sampling windows, culture media formulation, incubator conditions, and operator-dependent handling can generate centre-specific signatures that mimic biology in single-site studies but weaken or invert in external cohorts [461, 462, 482, 483]
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[PMID: 38996787] PubMed record related to this compound for laboratory literature review
Induction of pyruvate carboxylase can allow tumor cells to use glucose-derived pyruvate instead of glutamine for anaplerosis, inducing a glutamine-independent growth [106-108]