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Adverse events caused treatment discontinuation in 4.3%, 7.1%, 6.2%, and 2.6% of participants receiving 5-mg, 10-mg, 15-mg tirzepatide doses and placebo, respectively [49]
Analysis of tissue samples found that GLP-1 receptor proteins were most numerous in the pancreas, consistent with the drugs' known benefits in diabetes, but the heart had the second-highest concentration
It is almost always temporary and resolves once weight stabilizes
This means it works on GLP-1, as well as another receptor called glucose-dependent insulinotropic polypeptide, which also releases insulin
Andrade C (2014) Cause versus association in observational studies in psychopharmacology
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