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Mandrika and colleagues (Biochem Pharmacol, 2001, PMID 11239505) examined melanocortin peptides on NF-B DNA binding in RAW 264.7 macrophage-like cells and reported evidence for dual mechanisms of action, and Kannengiesser and colleagues (Inflamm Bowel Dis, 2008, PMID 18092346) reported effects in murine colitis models that were partly independent of MC1R

Rushing to higher concentrations before lower ones have demonstrated their effects leads to unnecessary escalation

By combining SLU-PP-332 and 5-Amino-1MQ, researchers can investigate multi-pathway interactions and potential synergistic effects

"I probably stopped at every portajohn along the way," he adds

He was considering adding 0.5mg oral BPC-157 on top, but ended up sticking to the dosage after some discussion within the peptide community

Example for Lau 2021 monotherapy (4.5 mg dose): 5 mg + 2 ml BAC = 2.5 mg/ml