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Hours after the initial trigger, mast cells produce and secrete certain chemokines (TNF, CCL2, CCL8) and renin.[ref] The different mediators released can lead to different symptoms of mast cell activation syndrome: Histamine leads to headaches, migraines, low blood pressure, itching, stomach acid release (and much more) Tryptase causes inflammation and fibrinogen lysis

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ET-1, a vasoconstrictor peptide originating from endothelial cells, exerts its effects through endothelin receptors and is correlated with cardiovascular disease severity

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Discussion The present report is based on an extensive immunohistochemical study of the GLP1R status in human thyroid and pancreatic tissues with a specific and well-validated monoclonal GLP1R antibody, 24 and also compares and further validates the obtained data with in situ ligand binding