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Tirzepatide operates through a sophisticated dual hormone receptor mechanism that targets both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors
Risks And Contraindications GLP 1 therapy can cause nausea, early fullness, reflux, constipation, or diarrhea, most often during dose increases
It reduces hunger signals to the brain, increases feelings of fullness, and initially slows gastric emptying, making it easier to adhere to a reduced-calorie diet
The gradual titration is critical for minimizing side effects
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