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These genes usually participate in intestinal immunity, the nuclear factor B (NF-B) signaling pathway, cytochrome P450 metabolism and melanoma formation.34 It has been confirmed that aloe leaves can inhibit CYP3A and CYP2D6 expression in vivo and that rhubarb can inhibit the P450 family through antimutation actions.35 DNA microarray analysis indicated that in tissues with MC, CYP3A4 expression was significantly decreased compared with that in normal tissue
these data highlight the potential eminent role of ROS modulation in anticancer combinatorial therapies 162,163
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10.1039/D0FO02624G 125 WangG.HuangS.CaiS.YuH.WangY.ZengX.et al
