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Existing GSDMD covalent inhibitors (disulfiram, necrosulfonamide, dimethyl fumarate) all target Cys191, but their impact on palmitoylation is unknown, highlighting the potential of developing palmitoylation-site-specific modulators for IBD (186188)
Given its prevalence and the substantial improvement in symptoms we typically see with treatment, I recommend testing for mold toxicity in most (but not all) of the individuals I treat.
10.1136/jnnp-2014-310183 J
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Kirino, Y
J Eye Mov Res
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