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The disease burden was similarly calculated as the sum of the histopathological changes in a mouse and severity of neoplastic and renal lesions was assessed using an established grading system
Their etiology is not clear and it may represent a physiologic or reactive process
Suppression of Mn-SOD expression using small interfering RNA increased superoxide production by approximately 70% in HGSOC cells, which led to enhanced cell proliferation in vitro and increased aggressiveness of tumor growth in vivo
It should be noted that eryptotic RBCs are cleared from the circulation in an efferocytosis-dependent fashion within minutes, in contrast to senescent erythrocytes [77], which require days to be engulfed by macrophages and cleared [72]
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