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The prospect of combining health benefits, including improved metabolic outcomes and reduced cardiovascular risks, adds another layer of optimism
Trends Pharmacol Sci (2020) 41(2):12338
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however, glucagon receptor activation can also increase heart rate and cardiac inotropy, and the net haemodynamic effect of this pathway in humans remains uncertain It is important to emphasise that these mechanistic explanations are working hypotheses
Schematic illustrations in Figs
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