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Excessive use may lead to skin irritation

More importantly, the human studies that now exist directly contradict the animal findings

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Another analysis of nine studies mostly in individuals with obesity or older adults found that people lost an average of 2.9 pounds (lbs), or 1.3 kilograms (kg), more weight while taking L-carnitine

The Authors reported that treatment with incretins significantly suppressed the FSH-induced synthesis of progesterone through the inhibition of the expression of progestogenic factors and enzymes, whereas there was no significant effect on oestrogen synthesis by rat granulosa cells, thus suggesting the possible role of GLP-1 RA in the treatment of dysregulated steroidogenesis in PCOS [43]

Additionally, there are ongoing clinical trials to further explore the effectiveness of long-acting GLP-1s in individuals with T1D and insulin resistance